The 49ers beat the Rams 27–7 at a neutral site, moving to 1–0. The Rams fell to 0–1.
For the 49ers, Brock Purdy went 25-for-34 for 205 yards with 3 touchdowns and 1 interception. Christian McCaffrey ran for 68 yards on 10 carries. Demarcus Robinson caught 2 passes for 50 yards and a touchdown.
For the Rams, Matthew Stafford went 15-for-25 for 155 yards with 1 interception. Puka Nacua caught 5 passes for 74 yards.
On defense, Renardo Green (49ers) had an interception and Quentin Lake (Rams) had an interception.
Recaps are written automatically from the final score and box score: player stats from nflverse (CC BY 4.0).
49ers quarterback Brock Purdy against Rams quarterback Matthew Stafford. Lineups as listed before kickoff (49ers: Sep 10, 2026, 8:01 AM ET; Rams: Sep 10, 2026, 8:01 AM ET).
RDE#99 Aaron Donald Out (not injury related - resting player)Next up: Braden Fiske
WLB#0 Byron YoungNext up: Josaiah Stewart
LILB#53 Nate LandmanNext up: Grant Stuard
RILB#48 Omar SpeightsNext up: Shaun Dolac
SLB#95 Myles GarrettNext up: Desjuan Johnson
LCB#35 Jaylen WatsonNo backup listed
SS#5 Kamren KinchensNext up: Jaylen McCollough
FS#3 Kam CurlNo backup listed
RCB#22 Trent McDuffieNext up: Emmanuel Forbes Jr.
Two tight ends: the top two receivers stay on the field and the second tight end lines up on the left end. Quarterback shown under center, where the 49ers lined him up on most snaps. Players beyond the listed starters come from the depth-chart order: this is who is most likely in, not a team announcement.
RDE#99 Aaron Donald Out (not injury related - resting player)Next up: Braden Fiske
WLB#0 Byron YoungNext up: Josaiah Stewart
LILB#53 Nate LandmanNext up: Grant Stuard
RILB#48 Omar SpeightsNext up: Shaun Dolac
SLB#95 Myles GarrettNext up: Desjuan Johnson
LCB#35 Jaylen WatsonNo backup listed
SS#5 Kamren KinchensNext up: Jaylen McCollough
FS#3 Kam CurlNo backup listed
RCB#22 Trent McDuffieNext up: Emmanuel Forbes Jr.
I-formation: two receivers and one tight end, with the quarterback under center and a fullback and running back stacked behind him. Two-back sets: 28% of snaps in this game. Players beyond the listed starters come from the depth-chart order: this is who is most likely in, not a team announcement.
RDE#99 Aaron Donald Out (not injury related - resting player)Next up: Braden Fiske
WLB#0 Byron YoungNext up: Josaiah Stewart
LILB#53 Nate LandmanNext up: Grant Stuard
RILB#48 Omar SpeightsNext up: Shaun Dolac
SLB#95 Myles GarrettNext up: Desjuan Johnson
LCB#35 Jaylen WatsonNo backup listed
SS#5 Kamren KinchensNext up: Jaylen McCollough
FS#3 Kam CurlNo backup listed
RCB#22 Trent McDuffieNext up: Emmanuel Forbes Jr.
Four receivers and no tight end: the next receiver on the depth chart comes in. Quarterback shown under center, where the 49ers lined him up on most snaps. Empty-backfield sets: 22% of snaps in this game. Players beyond the listed starters come from the depth-chart order: this is who is most likely in, not a team announcement.
RDE#99 Aaron Donald Out (not injury related - resting player)Next up: Braden Fiske
WLB#0 Byron YoungNext up: Josaiah Stewart
LILB#53 Nate LandmanNext up: Grant Stuard
RILB#48 Omar SpeightsNext up: Shaun Dolac
SLB#95 Myles GarrettNext up: Desjuan Johnson
LCB#35 Jaylen WatsonNo backup listed
SS#5 Kamren KinchensNext up: Jaylen McCollough
FS#3 Kam CurlNo backup listed
RCB#22 Trent McDuffieNext up: Emmanuel Forbes Jr.
Defense shown in its base front.
Rams offense vs 49ers defense
Rams in this game: shotgun 50%, under center 50%, pistol 0% · one back 77%, two backs 22%, empty 2% · motion 47% (60 charted snaps).
As the team lists it: three receivers, one tight end and one running back. Quarterback shown in the shotgun, where the Rams lined him up on most snaps.
Two tight ends: the top two receivers stay on the field and the second tight end lines up on the left end. Quarterback shown in the shotgun, where the Rams lined him up on most snaps. Players beyond the listed starters come from the depth-chart order: this is who is most likely in, not a team announcement.
I-formation: two receivers and one tight end, with the quarterback under center and a fullback and running back stacked behind him. Two-back sets: 22% of snaps in this game. Players beyond the listed starters come from the depth-chart order: this is who is most likely in, not a team announcement. No fullback on the depth chart, so the second tight end, Tyler Higbee, is shown at fullback.
Four receivers and no tight end: the next receiver on the depth chart comes in. Quarterback shown in the shotgun, where the Rams lined him up on most snaps. Empty-backfield sets: 2% of snaps in this game. Players beyond the listed starters come from the depth-chart order: this is who is most likely in, not a team announcement.